Gmnc Gene Summary [Mouse]
Predicted to enable chromatin binding activity. Involved in DNA replication. Acts upstream of or within several processes, including cerebrospinal fluid circulation; multi-ciliated epithelial cell differentiation; and seminiferous tubule development. Predicted to be located in extracellular region. Predicted to be active in nucleus. Is expressed in brain; bronchus; female reproductive system; olfactory epithelium; and respiratory system epithelium. Orthologous to human GMNC (geminin coiled-coil domain containing). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Gmnc |
| Official Name | geminin coiled-coil domain containing [Source:MGI Symbol;Acc:MGI:2685452] |
| Ensembl ID | ENSMUSG00000068428 |
| Bio databases IDs | |
| Aliases | geminin coiled-coil domain containing |
| Synonyms | GEMC1, geminin coiled-coil domain containing, Gm1778, Gm606, RGD1563170 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmnc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain found in the geminin family
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmnc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- DNA replication
- negative regulation of cell cycle
- negative regulation of DNA replication
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding