Ccne1

Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA replication initiation; chromosome organization; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; eye; and spleen. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccne1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ccne1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccne1 gene, providing context for its role in the cell.