Mcidas Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cilium assembly; seminiferous tubule development; and spermatogenesis. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in brain; female reproductive system; liver; and respiratory system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 42. Orthologous to human MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcidas |
| Official Name | multiciliate differentiation and DNA synthesis associated cell cycle protein [Source:MGI Symbol;Acc:MGI:3648807] |
| Ensembl ID | ENSMUSG00000074651 |
| Bio databases IDs | |
| Aliases | multiciliate differentiation and DNA synthesis associated cell cycle protein |
| Synonyms | CILD42, EG622408, Gm6320, IDAS, LOC686629, MCI, MCIN, multiciliate differentiation and DNA synthesis associated cell cycle protein, Multicilin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcidas often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- coiled-coil domain found in the geminin family
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcidas gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of DNA-dependent DNA replication initiation
- negative regulation of cell cycle
- negative regulation of DNA replication
- positive regulation of transcription from RNA polymerase II promoter
- motile cilium assembly
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleolus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding