Mgam Gene Summary [Mouse]
Enables alpha-1,4-glucosidase activity and amylase activity. Predicted to be involved in dextrin catabolic process and maltose catabolic process. Predicted to be located in apical plasma membrane. Is expressed in alimentary system; intestine; liver; midgut; and rectum. Orthologous to human MGAM (maltase-glucoamylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgam |
| Official Name | maltase-glucoamylase [Source:MGI Symbol;Acc:MGI:1203495] |
| Ensembl ID | ENSMUSG00000068587 |
| Bio databases IDs | |
| Aliases | maltase-glucoamylase |
| Synonyms | 6030407P20RIK, alpha-glucosidase, LOC434009, LOC665323, LOC679818, maltase-glucoamylase, MG, MGA, α-glucosidase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolases family 31
- Alpha amylase catalytic domain family
- pxlxp motif
- amylase
- glucan 1,4-alpha-glucosidase
- alpha-glucosidase
- N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
- enzyme
- protein binding
- Trefoil
- Galactose mutarotase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- disorder of coronary artery
- diabetes mellitus
- stroke
- non-insulin-dependent diabetes mellitus
- insulin resistance
- impaired glucose tolerance
- insulin-dependent diabetes mellitus
- polycystic ovary syndrome
- sepsis
- postprandial hyperglycemia
regulated by
- dexamethasone
- filgrastim
- Mrgpra2a (includes others)
- defensin
- miglitol
- acarbose
- voglibose
- celgosivir
- LRRFIP2
- mycophenolic acid
regulates
- maltose
- dextrin
- starch
role in cell
- recruitment
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secretory granule membrane
- tertiary granule membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- starch catabolic process
- maltose catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
- tertiary granule membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucan 1,4-alpha-glucosidase activity
- alpha-glucosidase activity
- protein binding
- amylase activity
- maltose alpha-glucosidase activity
- catalytic activity
- carbohydrate binding