Zmynd11 Gene Summary [Mouse]
Enables methylated histone binding activity; transcription corepressor activity; and zinc ion binding activity. Involved in regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; limb mesenchyme; and oocyte. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zmynd11 |
| Official Name | zinc finger, MYND domain containing 11 [Source:MGI Symbol;Acc:MGI:1913755] |
| Ensembl ID | ENSMUSG00000021156 |
| Bio databases IDs | |
| Aliases | zinc finger, MYND domain containing 11 |
| Synonyms | 2210402G22Rik, BS69, MRD30, zinc finger, MYND domain containing 11, zinc finger MYND-type containing 11, zinc finger, MYND-type containing 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zmynd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- MYND finger
- transcription co-repressor
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Bromodomain
- zinc ion binding
- double-stranded DNA binding
- phd-bromo-pwwp domain
- PHD finger superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- lung squamous cell carcinoma
- squamous cell lung cancer
- rheumatoid arthritis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hereditary disorder
- autosomal dominant mental retardation type 30
- organismal death
- syndromic complex neurodevelopmental disorder
role in cell
- apoptosis
- migration
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zmynd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of extrinsic apoptotic signaling pathway
- defense response to virus
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- chromatin organization
- negative regulation of JNK cascade
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription corepressor activity
- methylated histone residue binding
- double-stranded DNA binding