Slc7a14 Gene Summary [Mouse]
Enables gamma-aminobutyric acid transmembrane transporter activity. Involved in gamma-aminobutyric acid import. Located in lysosomal membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; hemolymphoid system; and sensory organ. Used to study blindness and sensorineural hearing loss. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to human SLC7A14 (solute carrier family 7 member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc7a14 |
| Official Name | solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 [Source:MGI Symbol;Acc:MGI:3040688] |
| Ensembl ID | ENSMUSG00000069072 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 |
| Synonyms | A930013N06, FLJ37228, KIAA1613, LOC681347, PPP1R142, solute carrier family 7 (cationic amino acid transporter, y+ system), member 14, solute carrier family 7 member 14, solute carrier family 7, member 14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc7a14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amino acid permease (GABA permease)
- amino acid permease (yeast)
- amino acid permease
- L-type amino acid transporter
- gamma-aminobutyrate transporter
- protein binding
- cationic amino acid transport permease
- ion channel
- amino acid transporter
- C-terminus of AA_permease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- lysosome membrane
- nucleoplasm
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc7a14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gamma-aminobutyric acid import
- amino acid transport
- amino acid transmembrane transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- lysosomal membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-gamma-aminobutyric acid transmembrane transporter activity
- amino acid transmembrane transporter activity