Cylc1 Gene Summary [Mouse]
Enables protein homodimerization activity. Acts upstream of or within several processes, including acrosome assembly; maintenance of cell number; and single fertilization. Is active in acrosomal membrane and perinuclear theca. Used to study male infertility. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 8. Orthologous to human CYLC1 (cylicin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cylc1 |
| Official Name | cylicin, basic protein of sperm head cytoskeleton 1 [Source:MGI Symbol;Acc:MGI:1914657] |
| Ensembl ID | ENSMUSG00000073001 |
| Bio databases IDs | |
| Aliases | cylicin, basic protein of sperm head cytoskeleton 1 |
| Synonyms | 4930401M13RIK, CYCL1, cylicin 1, cylicin, basic protein of sperm head cytoskeleton 1, LO016976.1, SPGFX8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cylc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- protein binding
- Cylicin N-terminus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- acrosome
- sperm head
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cylc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoskeletal calyx
- nucleus
- acrosomal matrix
Molecular Function
What the gene product does at the molecular level
- structural molecule activity
- structural constituent of cytoskeleton