Top2a Gene Summary [Mouse]
Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including chromosome organization; embryonic cleavage; and positive regulation of transcription by RNA polymerase II. Located in chromosome and nucleus. Is active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Top2a |
| Official Name | topoisomerase (DNA) II alpha [Source:MGI Symbol;Acc:MGI:98790] |
| Ensembl ID | ENSMUSG00000020914 |
| Bio databases IDs | |
| Aliases | topoisomerase (DNA) II alpha |
| Synonyms | DNA TOPOISOMERASE II alpha, DNA TOPOISOMERASE II α, TOP2, TOP2alpha, Top2a: topoisomerase (dna) ii α (170kd), TOPIIA, TOPO2 alpha, TOPO2 α, topoisomerase (DNA) II alpha, topoisomerase (DNA) II α, Topoisomerase II alpha, Topoisomerase II α, TP2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Top2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal associated domain of TOPRIM
- TopoisomeraseII
- Histidine kinase-like ATPase domain
- ATP binding
- DNA gyrase B
- chromatin binding
- enzyme
- cleavage site
- ATPase domain
- 3F3/2 epitope
- TOP4c
- DNA gyrase/topoisomerase IV, subunit A
- core domain, structural
- dimerization domain
- DNA topoisomerase (ATP-hydrolysing)
- catalytic domain
- protein kinase C binding
- walker type A motif
- nuclear localization sequence
- TopoII_MutL_Trans
- TOPRIM
- Toprim domain
- ubiquitin binding
- DNA bending protein
- glucose-regulated destruction domain
- protein binding
- DNA dependent ATPase
- magnesium ion binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- DNA topoisomerase
- protein homodimerization
- DNA Topoisomerase IV
- Histidine kinase-like ATPases
- DTHCT (NUC029) region
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Top2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- asthma
- multiple sclerosis
- leukemia
- mycosis fungoides
- systemic lupus erythematosus
- ophthalmia
- acute lymphoblastic leukemia
- lymphoma
- invasive breast cancer
role in cell
- accumulation in
- expression in
- apoptosis
- cell death
- accumulation
- survival
- contact growth inhibition
- meiosis
- structural integrity
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- centrosome
- centriole
- cytoplasmic aggregates
- nuclear foci
- chromosome
- nucleoplasm
- nucleolus derived foci
- nucleoli
- nuclear scaffolds
- kinetochores
- centromeres
- chromosomal arms
- centromeric heterochromatin
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Top2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic cleavage
- sister chromatid segregation
- female meiosis
- DNA ligation
- resolution of meiotic recombination intermediates
- chromosome segregation
- DNA topological change
- regulation of circadian rhythm
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- hemopoietic progenitor cell differentiation
- rhythmic process
- positive regulation of retroviral genome replication
- positive regulation of apoptotic process
- apoptotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- centriole
- cytoplasm
- DNA topoisomerase complex (ATP-hydrolyzing)
- nuclear chromosome
- macromolecular complex
- nucleolus
- chromosome, centromeric region
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- DNA-dependent ATPase activity
- protein homodimerization activity
- DNA binding, bending
- chromatin binding
- magnesium ion binding
- DNA binding
- ATP binding
- RNA binding
- protein binding
- ubiquitin binding
- protein heterodimerization activity
- DNA topoisomerase (ATP-hydrolyzing) activity