Vma21 Gene Summary [Mouse]
Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in lysosome. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; heart; liver; lung; and triceps surae muscle. Human ortholog(s) of this gene implicated in X-linked myopathy with excessive autophagy. Orthologous to human VMA21 (vacuolar ATPase assembly factor VMA21). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vma21 |
| Official Name | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914298] |
| Ensembl ID | ENSMUSG00000073131 |
| Bio databases IDs | |
| Aliases | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) |
| Synonyms | 2610030H06Rik, LOC100912478, MEAX, RGD1566155, UPF0569, vacuolar ATPase assembly factor VMA21, VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), XMEA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vma21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- VMA21-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcoplasmic reticulum
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vma21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vacuolar proton-transporting V-type ATPase complex assembly
- regulation of ATPase activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER to Golgi transport vesicle membrane
- lysosome
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding