Esyt1 Gene Summary [Mouse]
Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including foregut; genitourinary system; nervous system; sensory organ; and spleen. Orthologous to human ESYT1 (extended synaptotagmin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esyt1 |
| Official Name | extended synaptotagmin-like protein 1 [Source:MGI Symbol;Acc:MGI:1344426] |
| Ensembl ID | ENSMUSG00000025366 |
| Bio databases IDs | |
| Aliases | extended synaptotagmin-like protein 1 |
| Synonyms | extended synaptotagmin 1, extended synaptotagmin-like protein 1, FAM62A, KIAA0747, MBC2, vp115 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esyt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid transporter
- Synaptotagmin-like mitochondrial-lipid-binding domain
- protein binding
- synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain superfamily
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- transporter
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- chronic periodontal disease
role in cell
- production in
- accumulation in
- phosphorylation in
- cytotoxicity
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esyt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- identical protein binding
- protein binding
- calcium ion binding
- phosphatidylinositol binding
- phosphatidylcholine binding
- calcium-dependent phospholipid binding