Pappa2 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase activity. Acts upstream of or within bone morphogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; long bone; nervous system; and retina layer. Orthologous to human PAPPA2 (pappalysin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pappa2 |
| Official Name | pappalysin 2 [Source:MGI Symbol;Acc:MGI:3051647] |
| Ensembl ID | ENSMUSG00000073530 |
| Bio databases IDs | |
| Aliases | pappalysin 2 |
| Synonyms | LOC680069, pappalysin 2, PAPP-E, PLAC3, SSDA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pappa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myxococcus cysteine-rich repeat
- CCP
- Concanavalin A-like lectin/glucanases superfamily
- metallopeptidase
- ZnMc
- LamG
- peptidase
- LNR domain
- Sushi repeat (SCR repeat)
- SUSHI repeat
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Pappa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- myocardial infarction
- Dauber-Argente type of short stature
- growth failure
- idiopathic scoliosis
- central nervous system cancer
- measles
regulates
role in cell
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pappa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- response to salt stress
- regulation of cell growth
- proteolysis
- bone morphogenesis
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity
- metallopeptidase activity