Pou2af1 Gene Summary [Mouse]
Enables DNA binding activity and transcription coactivator activity. Involved in cellular response to virus; germinal center B cell differentiation; and positive regulation of interleukin-6 production. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou2af1 |
| Official Name | POU domain, class 2, associating factor 1 [Source:MGI Symbol;Acc:MGI:105086] |
| Ensembl ID | ENSMUSG00000032053 |
| Bio databases IDs | |
| Aliases | POU domain, class 2, associating factor 1 |
| Synonyms | BOB1, BOB.1, LOC684630, OBF-1, OBF.1, OCA-B, POU class 2 homeobox associating factor 1, POU domain, class 2, associating factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou2af1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- transcription co-activator
- myristoylation sequence
- transcription cofactor
- protein binding
- POU domain, class 2, associating factor 1
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- COVID-19
- multiple sclerosis
- vascular dementia
- diabetic nephropathy
- agammaglobulinemia
- Hodgkin lymphoma
- Hodgkin disease
- chronic obstructive pulmonary disease
- mediastinal gray zone lymphoma
role in cell
- quantity
- proliferation
- apoptosis
- expression in
- phosphorylation in
- number
- upregulation in
- function
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou2af1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germinal center B cell differentiation
- humoral immune response
- positive regulation of interleukin-6 production
- positive regulation of transcription from RNA polymerase II promoter
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- POU domain binding