Ubtfl1 Gene Summary [Mouse]
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Acts upstream of or within blastocyst growth; embryo implantation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in early conceptus and oocyte. Orthologous to several human genes including UBTFL1 (upstream binding transcription factor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubtfl1 |
| Official Name | upstream binding transcription factor, RNA polymerase I-like 1 [Source:MGI Symbol;Acc:MGI:3588290] |
| Ensembl ID | ENSMUSG00000074502 |
| Bio databases IDs | |
| Aliases | upstream binding transcription factor, RNA polymerase I-like 1 |
| Synonyms | B020006M18Rik, C11orf27, HMGPI, upstream binding transcription factor like 1, upstream binding transcription factor, RNA polymerase I-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubtfl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubtfl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase I transcriptional preinitiation complex assembly
- blastocyst growth
- transcription from RNA polymerase I promoter
- embryo implantation
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase I CORE element sequence-specific DNA binding
- core RNA polymerase I binding transcription factor activity