Tfip11 Gene Summary [Mouse]
Predicted to enable nucleic acid binding activity. Involved in spliceosomal complex disassembly. Located in extracellular matrix. Is expressed in several structures, including foregut; nervous system; nose; submandibular gland primordium; and tooth. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfip11 |
| Official Name | tuftelin interacting protein 11 [Source:MGI Symbol;Acc:MGI:1930075] |
| Ensembl ID | ENSMUSG00000029345 |
| Bio databases IDs | |
| Aliases | tuftelin interacting protein 11 |
| Synonyms | 2810002G02Rik, bK445C9.6, NTR1, Spp382, Srr1, STIP, STIP-1, TIP33, TIP39, tuftelin interacting protein 11, Tuftelin interacting protein 33 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfip11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tuftelin interacting protein N terminal
- G-patch domain
- protein binding
- GC-rich sequence DNA-binding factor-like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- interchromatin granule cluster fractions
- catalytic step 2 spliceosome
- Cytoplasm
- Nucleus
- spliceosomes
- nucleoplasm
- nucleoli
- nuclear speckles
- extracellular matrix
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfip11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of double-strand break repair via nonhomologous end joining
- protection from non-homologous end joining at telomere
- spliceosomal complex disassembly
- negative regulation of protein complex assembly
- RNA processing
- negative regulation of protein binding
- biomineral tissue development
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- spliceosomal complex
- extracellular matrix
- nucleolus
- U2-type post-mRNA release spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding