Sp5 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within bone morphogenesis and post-anal tail morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo ectoderm; and embryo mesenchyme. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sp5 |
| Official Name | trans-acting transcription factor 5 [Source:MGI Symbol;Acc:MGI:1927715] |
| Ensembl ID | ENSMUSG00000075304 |
| Bio databases IDs | |
| Aliases | trans-acting transcription factor 5 |
| Synonyms | Sp5 transcription factor, trans-acting transcription factor 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- androgenic alopecia
- hepatoblastoma
- yolk sac neoplasm
- germ cell neoplasia
- cholesteatoma
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- bone morphogenesis
- cellular response to organic cyclic compound
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity