Foxq1 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within hair follicle morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; phalanx; and sensory organ. Orthologous to human FOXQ1 (forkhead box Q1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxq1 |
| Official Name | forkhead box Q1 [Source:MGI Symbol;Acc:MGI:1298228] |
| Ensembl ID | ENSMUSG00000038415 |
| Bio databases IDs | |
| Aliases | forkhead box Q1 |
| Synonyms | forkhead box Q1, HFH-1, Hfh1l, sa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxq1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FH_FOX
- double-stranded DNA binding
- nucleic acid binding
- sequence-specific DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- colon carcinoma
- colon epithelial cancer
- diabetic nephropathy
- HER2 negative hormone receptor negative breast cancer
- colorectal cancer
- hepatocellular carcinoma
- colon adenoma
- colon adenoma formation
role in cell
- expression in
- invasion by
- quantity
- proliferation
- migration
- septation
- paclitaxel resistance
- cisplatin resistance
- formation by
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxq1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell differentiation
- hair follicle morphogenesis
- anatomical structure morphogenesis
- negative regulation of neuron apoptotic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity