Cyp11b1 Gene Summary [Mouse]
Enables corticosterone 18-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp11b1 |
| Official Name | cytochrome P450, family 11, subfamily b, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88583] |
| Ensembl ID | ENSMUSG00000075604 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 11, subfamily b, polypeptide 1 |
| Synonyms | Cp11ba, CPN1, Cyp11b, Cyp11b3, CYPXIB1, CYPXIB3, cytochrome P450, family 11, subfamily b, polypeptide 1, cytochrome P450, family 11, subfamily b, polypeptide 3, FHI, LOC100910462, LOC102557389, P45011 beta, P45011 β, P450C11, P450C11 beta, P450C11 β, RATCP11BA |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp11b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- steroid 11beta-monooxygenase
- Cytochrome P450
- corticosterone 18-monooxygenase
- enzyme
- heme binding
- steroid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria