Nr5a2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including gonad development; positive regulation of biosynthetic process; and positive regulation of cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; cholesterol homeostasis; and pancreas morphogenesis. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; ear; early conceptus; and gonad. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr5a2 |
| Official Name | nuclear receptor subfamily 5, group A, member 2 [Source:MGI Symbol;Acc:MGI:1346834] |
| Ensembl ID | ENSMUSG00000026398 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 5, group A, member 2 |
| Synonyms | B1F, B1F2, CPF, D1Ertd308e, FTF, FTF-2, FTZ-F1, FTZ-F1beta, hB1F-2, LRH-1, nuclear receptor subfamily 5 group A member 2, nuclear receptor subfamily 5, group A, member 2, UF2-H3B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nr5a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ftz F1 box
- transcription regulator
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription factor binding
- AF-2 transcription activation domain
- chromatin binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- Pka phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- phospholipid binding
- DNA binding domain
- nucleic acid binding
- alpha helix
- protein binding
- sequence-specific DNA binding
- DNA binding
- AFH domain
- double-stranded DNA binding
- hinge domain
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nr5a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- liver cancer
- open-angle glaucoma
- ulcerative colitis
- inflammatory bowel disease
- osteoporosis
- myopia
- nicotine dependence
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- expression in
- phosphorylation in
- binding in
- migration
- Gap 0-Gap 1 phase
- proliferation
- activation in
- activation
- differentiation
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nucleoplasm
- PML nuclear bodies
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nr5a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acinar cell differentiation
- pancreas morphogenesis
- embryo development ending in birth or egg hatching
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- bile acid metabolic process
- cholesterol homeostasis
- tissue development
- regulation of cell proliferation
- hormone-mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- homeostatic process
- positive regulation of viral genome replication
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- phospholipid binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity