Airn Gene Summary [Mouse]
This gene is a paternally expressed imprinted gene. Alternatively spliced transcript variants have been produced from this gene and they are all long non-coding RNAs. These variants share the same 5' exon, and their 3' exons are divergent. The 5' exon overlaps the intron 2 of the Igf2r gene on the opposite strand. The Igf2r intron 2 contains a CpG island, which is a promoter and drives the expression of this gene. This gene is responsible for silencing Igf2r, and the flanking Slc22a2 and Slc22a3 genes in the imprinted gene cluster. It regulates transcription of these genes through epigenetic modifications. [provided by RefSeq, Jan 2013]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Airn |
| Official Name | antisense Igf2r RNA [Source:MGI Symbol;Acc:MGI:1353471] |
| Ensembl ID | ENSMUSG00000078247 |
| Bio databases IDs | |
| Aliases | antisense Igf2r RNA |
| Synonyms | 2810051F02RIK, 2810434M15Rik, AI256653, Air, antisense Igf2r RNA, B930018I07Rik, D17Ertd663e, IGF2RAS |
| Species | Mouse, Mus musculus |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac fibrosis
- alcoholic fatty liver disease
- hepatic injury
- diabetic nephropathy
regulated by
- ethanol
- carbon tetrachloride
- oleic acid
role in cell
- expression in
- apoptosis
- phosphorylation in
- binding in
- proliferation
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome