Igf2bp2 Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity; mRNA 5'-UTR binding activity; and translation regulator activity. Involved in negative regulation of translation. Acts upstream of or within cold-induced thermogenesis and energy homeostasis. Predicted to be located in P-body; cytoplasmic stress granule; and cytoskeleton. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adipose tissue; early conceptus; gonad; nervous system; and otocyst. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf2bp2 |
| Official Name | insulin-like growth factor 2 mRNA binding protein 2 [Source:MGI Symbol;Acc:MGI:1890358] |
| Ensembl ID | ENSMUSG00000033581 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor 2 mRNA binding protein 2 |
| Synonyms | C330012H03Rik, Hepatocellular carcinoma autoantigen p62, IMP-2, insulin-like growth factor 2 mRNA binding protein 2, Neilsen, RGD1305614, VICKZ2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igf2bp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- mRNA 5' UTR binding
- KH domain
- K homology (KH) RNA-binding domain, type I
- arCOG04150 universal archaeal KH domain protein
- RNA recognition motif
- protein binding activity, bridging
- K homology RNA-binding domain
- protein binding
- RNA-binding domain
- translation regulator
Pathways
Biological processes and signaling networks where the Igf2bp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- experimental autoimmune encephalomyelitis
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- osteoporosis
- ovarian cancer
- periodontitis
- hypothyroidism
- laryngeal squamous cell carcinoma
role in cell
- cell viability
- production in
- migration
- expression in
- apoptosis
- growth
- proliferation
- phosphorylation in
- invasion by
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytoskeleton
- perinuclear region
- Nucleus
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igf2bp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- energy homeostasis
- nervous system development
- anatomical structure morphogenesis
- regulation of cytokine production
- negative regulation of translation
- CRD-mediated mRNA stabilization
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasmic stress granule
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation regulator activity
- protein binding
- RNA binding
- mRNA 5'-UTR binding
- translation regulator activity, nucleic acid binding
- mRNA 3'-UTR binding