Magea8 Gene Summary [Mouse]
Predicted to enable caspase binding activity and histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; endoplasmic reticulum; and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; heart; liver; and reproductive system. Orthologous to human MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magea8 |
| Official Name | MAGE family member A8 [Source:MGI Symbol;Acc:MGI:1333827] |
| Ensembl ID | ENSMUSG00000079350 |
| Bio databases IDs | |
| Aliases | MAGE family member A8 |
| Synonyms | Magea1, Magea2, Magea5, Magea6, Magea8, MAGE family member A1, MAGE family member A2, MAGE family member A3, MAGE family member A5, MAGE family member A6, MAGE family member A8, RGD1565778 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Magea8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Melanoma associated antigen family N terminal
- MAGE homology domain
- protease binding
- transcription factor binding
- histone deacetylase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- beta-estradiol
- FGF7
- Large T Antigen
regulates
- TP53
- DNA promoter
- DNA endogenous promoter
- histone H3
role in cell
- expression in
- methylation in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nuclear bodies
- PML nuclear bodies