Fgf7 Gene Summary [Mouse]
Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of DNA-templated transcription and regulation of synapse maturation. Acts upstream of or within morphogenesis of an epithelium; positive regulation of cell population proliferation; and regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in Golgi apparatus and extracellular region. Is active in GABA-ergic synapse and postsynapse. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human FGF7 (fibroblast growth factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf7 |
| Official Name | fibroblast growth factor 7 [Source:MGI Symbol;Acc:MGI:95521] |
| Ensembl ID | ENSMUSG00000027208 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 7 |
| Synonyms | Fgf5b, fibroblast growth factor 7, HBGF-7, keratinocyte growth factor, KGF, KGF-1, KGF-7, KGF/FGF7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 2 fibroblast growth factor receptor binding
- chemoattractant
- protein binding
- loop domain
- heparin binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- breast cancer
- seizures
- epileptic seizure
- weight loss
- papillary thyroid carcinoma
role in cell
- degradation
- growth
- activation in
- quantity
- expression in
- migration
- phosphorylation in
- proliferation
- cell death
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- postsynaptic region
- Golgi Apparatus
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- positive chemotaxis
- secretion by lung epithelial cell involved in lung growth
- positive regulation of cell proliferation
- response to wounding
- epidermis development
- fibroblast growth factor receptor signaling pathway
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
- branching involved in salivary gland morphogenesis
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- positive regulation of keratinocyte proliferation
- positive regulation of cell division
- positive regulation of transcription, DNA-dependent
- positive regulation of keratinocyte migration
- positive regulation of epithelial cell proliferation
- positive regulation of peptidyl-tyrosine phosphorylation
- lung development
- signal transduction
- positive regulation of MAPK cascade
- organ morphogenesis
- positive regulation of gene expression
- myoblast proliferation
- cell differentiation
- endothelial cell proliferation
- hair follicle morphogenesis
- positive regulation of myoblast proliferation
- positive regulation of endothelial cell proliferation
- regulation of cell migration
- actin cytoskeleton organization
- mesenchymal cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- chemoattractant activity
- heparin binding
- type 2 fibroblast growth factor receptor binding