Pcgf3 Gene Summary [Rat]

The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
Pcgf3
Official Name
polycomb group ring finger 3 [Source:RGD Symbol;Acc:1311479]
Ensembl ID
ENSRNOG00000000062
Bio databases IDs NCBI: 305624 Ensembl: ENSRNOG00000000062
Aliases polycomb group ring finger 3
Synonyms 2310035N15Rik, D630042K08Rik, DONG1, E430039C14, polycomb group ring finger 3, RNF3, RNF3A
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcgf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RAWUL domain RING finger- and WD40-associated ubiquitin-like
  • ubiquitin protein ligase activity
  • Ubl1_cv_Nsp3_N-like
  • RING finger (Really Interesting New Gene) domain and U-box domain superfamily
  • Ring finger
  • enzyme
  • protein binding
  • Zinc finger, C3HC4 type (RING finger)

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • schizophrenia
  • non-insulin-dependent diabetes mellitus
  • pervasive developmental disorder
  • Parkinson disease
regulated by
  • CDKN1A
  • Bacillus anthracis Sterne strain 7702
  • HNRNPA1
  • doxorubicin
role in cell
  • JG-231 sensitivity
  • TAK-901 sensitivity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm
  • X chromosome

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Pcgf3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • random inactivation of X chromosome
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • PRC1 complex
  • X chromosome
  • PcG protein complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • metal ion binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.