Pcgf3 Gene Summary [Mouse]
Enables histone H2AK119 ubiquitin ligase activity. Involved in random inactivation of X chromosome. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in several structures, including branchial arch; central nervous system; limb; otocyst; and urinary system. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcgf3 |
| Official Name | polycomb group ring finger 3 [Source:MGI Symbol;Acc:MGI:1916837] |
| Ensembl ID | ENSMUSG00000033623 |
| Bio databases IDs | |
| Aliases | polycomb group ring finger 3 |
| Synonyms | 2310035N15Rik, D630042K08Rik, DONG1, E430039C14, polycomb group ring finger 3, RNF3, RNF3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcgf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RAWUL domain RING finger- and WD40-associated ubiquitin-like
- ubiquitin protein ligase activity
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- X chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcgf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- random inactivation of X chromosome
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- X chromosome
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding