Pfdn4 Gene Summary [Rat]
Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to be located in mitochondrion and nucleus. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfdn4 |
| Official Name | prefoldin subunit 4 [Source:RGD Symbol;Acc:2324021] |
| Ensembl ID | ENSRNOG00000050932 |
| Bio databases IDs | |
| Aliases | prefoldin subunit 4 |
| Synonyms | 0610025M10Rik, 1810063B06Rik, C-1, PFD4, prefoldin 4, PREFOLDING 4, prefoldin subunit 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pfdn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- prefoldin
- protein binding
- chaperone binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pfdn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- protein folding
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- prefoldin complex
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- unfolded protein binding
- beta-amyloid binding