RT1-DOb Gene Summary [Rat]
Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; and peptide antigen assembly with MHC class II protein complex. Predicted to be located in lysosome. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Orthologous to human HLA-DOB (major histocompatibility complex, class II, DO beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | RT1-DOb |
| Official Name | RT1 class II, locus DOb [Source:RGD Symbol;Acc:1595814] |
| Ensembl ID | ENSRNOG00000000454 |
| Bio databases IDs | |
| Aliases | RT1 class II, locus DOb |
| Synonyms | A-beta-2, A-β-2, DOB, H-2Ab, H2-Ab2, H-2I, H2-IAb2, H2-Ob, histocompatibility 2, O region beta locus, histocompatibility 2, O region β locus, I-A-B-B, major histocompatibility complex, class II, DO beta, major histocompatibility complex, class II, DO β, MHC Class II, DO beta, MHC Class II, DO β, Ob, RT1-Bb2, RT1 class II, locus DOb, RT1-DOb, vic1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rt1-Dob often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- MHC class II receptor
- dileucine internalization motif
- binding protein
- immunoglobulin domain
- transmembrane domain
- tyrosine internalization motif
- cytosolic tail domain
- transmembrane receptor
- Class II histocompatibility antigen, beta domain
Pathways
Biological processes and signaling networks where the Rt1-Dob gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Down syndrome
- insulin-dependent diabetes mellitus
- sarcoidosis
- schizophrenia
- chronic lymphocytic leukemia
- lung carcinoma
- lung carcinoma process
- breast cancer
- rheumatoid arthritis
regulates
- proinsulin
- HLA-DOB
- HLA-DOA
- MHC II (complex)
- HLA-DM
role in cell
- incorporation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular space
- cellular membrane
- lysosome
- Endoplasmic Reticulum
- MHC class II compartments
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rt1-Dob gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of antigen processing and presentation of peptide antigen via MHC class II
- positive regulation of T cell activation
- peptide antigen assembly with MHC class II protein complex
- adaptive immune response
- positive regulation of immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- MHC class II protein complex
- late endosome membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- peptide antigen binding
- MHC class II receptor activity
- MHC class II protein complex binding