Cd63 Gene Summary [Rat]
Involved in several processes, including negative regulation of epithelial cell migration; positive regulation of cell adhesion; and positive regulation of endocytosis. Located in extracellular exosome. Part of protein-containing complex. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd63 |
| Official Name | Cd63 molecule [Source:RGD Symbol;Acc:62080] |
| Ensembl ID | ENSRNOG00000007650 |
| Bio databases IDs | |
| Aliases | Cd63 molecule |
| Synonyms | AD1, CD63 antigen, CD63 molecule, HOP-26, LIMP, ME491, MLA1, OMA81H, Pltgp40, TSPAN30 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd63 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- binding protein
- protein binding
- cytosolic tail domain
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- androgenic alopecia
- psoriasis
- essential thrombocythemia
- tauopathy
- anaphylaxis
- polyuria
- dermatomyositis
- polydipsia
- severe acute respiratory syndrome
role in cell
- proliferation
- adhesion
- morphology
- phosphorylation in
- quantity
- differentiation
- activation
- binding in
- migration
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- tetraspanin-enriched microdomain
- multivesicular domain
- endolysosomal tubule
- intracellular membrane-bounded organelle
- intracellular compartment
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- microvesicles
- membrane surface
- cellular membrane
- endosomes
- vesicles
- lysosome
- secretory granule membrane
- granules
- cytosol
- MHC class II compartments
- microdomains
- endosome-lysosome compartments
- lysosome membrane
- endosomal compartment
- endosomal membrane
- nucleoplasm
- cytotoxic granule
- Weibel-Palade bodies
- late endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- melanosomes
- multivesicular bodies
- azurophil granules
- secretory granules
- membrane rafts
- membrane processes
- microvilli
- exosomes
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd63 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- positive regulation of receptor internalization
- protein transport
- endosome to melanosome transport
- pigment granule maturation
- cell migration
- positive regulation of integrin-mediated signaling pathway
- regulation of vascular endothelial growth factor signaling pathway
Cellular Component
Where in the cell the gene product is active
- lysosomal membrane
- plasma membrane
- nucleoplasm
- cell surface
- late endosome membrane
- extracellular space
- extracellular vesicular exosome
- melanosome
- intracellular membrane-bounded organelle
- endosome lumen
- platelet dense granule membrane
- endosome membrane
- multivesicular body membrane
- azurophil granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding