Phf1 Gene Summary [Rat]
Enables chromatin binding activity. Predicted to be involved in DNA repair-dependent chromatin remodeling and negative regulation of gene expression, epigenetic. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and site of double-strand break. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human PHF1 (PHD finger protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf1 |
| Official Name | PHD finger protein 1 [Source:RGD Symbol;Acc:1303205] |
| Ensembl ID | ENSRNOG00000000480 |
| Bio databases IDs | |
| Aliases | PHD finger protein 1 |
| Synonyms | D17Ertd455e, hPHF1, MTF2L2, PCL1, PHD finger protein 1, PHF2, TCTEX3, TDRD19C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone binding
- transcription regulator
- protein binding activity, bridging
- enzyme binding
- chromatin binding
- PHD finger superfamily
- transcription factor binding
- protein binding
- identical protein binding
- Tudor domain superfamily
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- atopic dermatitis
- endometrial stromal sarcoma
- endometrial sarcoma cancer
role in cell
- expression in
- growth
- apoptosis
- degradation in
- stabilization in
- binding in
- trimethylation in
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- site of double-strand break
- ESC/E(Z) complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- DNA binding
- identical protein binding
- protein binding
- metal ion binding
- methylated histone residue binding
- chromatin binding