Hoxa9 Gene Summary [Rat]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa9 |
| Official Name | homeobox A9 [Source:RGD Symbol;Acc:1310001] |
| Ensembl ID | ENSRNOG00000061871 |
| Bio databases IDs | |
| Aliases | homeobox A9 |
| Synonyms | ABD-B, homeobox A9, HOX1, HOX1.7, HOX1G, Hoxa9l, LOC100909740, LOC100911710, LOC103689925, RGD1310001 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxa9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Pbx binding domain
- nucleic acid binding
- basic tetrad
- double-stranded DNA binding
- Hox9 activation region
- enzyme binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplastic cell transformation
- organismal death
- basal-like breast cancer
- survival
- Hutchinson-Gilford progeria syndrome
- leukemogenesis
- leukemia
- metastatic colorectal cancer
role in cell
- expression in
- proliferation
- migration
- activation
- growth
- acetylation in
- differentiation
- activity
- transformation
- immortalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxa9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell activation
- negative regulation of myeloid cell differentiation
- male gonad development
- transcription, DNA-dependent
- spermatogenesis
- uterus development
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- single fertilization
- proximal/distal pattern formation
- embryonic skeletal system morphogenesis
- definitive hemopoiesis
- regulation of transcription from RNA polymerase II promoter
- mammary gland development
- response to testosterone stimulus
- prostate gland development
- embryonic forelimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- enzyme binding