Rpl21 Gene Summary [Rat]

Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in ribosome. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in hypotrichosis 12. Orthologous to human RPL21 (ribosomal protein L21). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rpl21
Official Name
ribosomal protein L21 [Source:RGD Symbol;Acc:68390]
Ensembl ID
ENSRNOG00000000957
Bio databases IDs NCBI: 79449 Ensembl: ENSRNOG00000000957
Aliases ribosomal protein L21
Synonyms 8430440E03Rik, eL21, HYPT12, L21, ribosomal protein L21
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpl21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • structural constituent of ribosome
  • Ribosomal protein L21e
  • protein binding
  • RNA binding

Pathways

Biological processes and signaling networks where the Rpl21 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • nonalcoholic fatty liver disease
  • metabolic syndrome X
  • breast adenocarcinoma
  • hypotrichosis type 12
  • nonalcoholic steatohepatitis
regulated by
  • testosterone
  • beta-estradiol
  • hydrogen peroxide
  • PPARA
  • LH
  • sirolimus
  • fingolimod
  • IL2
  • MYC
  • YAP1

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • ribosome
  • Nucleus
  • cytosol
  • nucleoli
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Rpl21 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cytoplasmic translation
  • translation

Cellular Component

Where in the cell the gene product is active
  • cytosolic ribosome
  • cytoplasm
  • membrane
  • cytosol
  • endoplasmic reticulum
  • cytosolic large ribosomal subunit
  • synapse

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • structural constituent of ribosome

Gene-Specific Assays for Results You Can Trust

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