Pcp2 Gene Summary [Rat]

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within G protein-coupled opsin signaling pathway. Predicted to be located in neuronal cell body. Orthologous to human PCP2 (Purkinje cell protein 2). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Pcp2
Official Name
Purkinje cell protein 2 [Source:RGD Symbol;Acc:1306217]
Ensembl ID
ENSRNOG00000000993
Bio databases IDs NCBI: 304195 Ensembl: ENSRNOG00000000993
Aliases Purkinje cell protein 2
Synonyms GPSM4, L7, MGC41903, PCD5, Purkinje cell protein 2, Purkinje cell protein 2 (L7)
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein regulatory motif
  • guanyl-nucleotide exchange factor
  • GoLoco motif
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • purkinje cell degeneration
regulated by
  • L-triiodothyronine
  • THRB
  • methimazole
  • THRA
  • aroclor 1254
  • sobetirome
  • GNB3
regulates
  • GNAO1
  • guanosine 5'-O-(3-thiotriphosphate)
  • GNAI1
  • GDP
role in cell
  • depolarization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Pcp2 gene, providing context for its role in the cell.

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • guanyl-nucleotide exchange factor activity