Timm44 Gene Summary [Rat]
Enables enzyme binding activity and protein-folding chaperone binding activity. Involved in cardiac muscle cell differentiation; intracellular protein transport; and response to 3,3',5-triiodo-L-thyronine. Located in mitochondrial inner membrane. Biomarker of diabetic retinopathy. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timm44 |
| Official Name | translocase of inner mitochondrial membrane 44 [Source:RGD Symbol;Acc:3864] |
| Ensembl ID | ENSRNOG00000001058 |
| Bio databases IDs | |
| Aliases | translocase of inner mitochondrial membrane 44 |
| Synonyms | 0710005E20RIK, D8Ertd118e, Mimt44, TIM44, translocase of inner mitochondrial membrane 44 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Timm44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tim44-like domain
- enzyme binding
- protein binding
- chaperone binding
- mitochondrial import inner membrane, translocase subunit
- Apolipophorin-III precursor (apoLp-III)
- transporter
Pathways
Biological processes and signaling networks where the Timm44 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Mitochondria
- cytosol
- mitochondrial cristae
- mitochondrial matrix
- mitochondrial inner membrane
- mitoplasts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Timm44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein import into mitochondrial matrix
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- chaperone binding