Cox4i1 Gene Summary [Rat]
Involved in response to nutrient. Predicted to be located in cytosol; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of respiratory chain complex IV. Biomarker of protein-energy malnutrition. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox4i1 |
| Official Name | cytochrome c oxidase subunit 4i1 [Source:RGD Symbol;Acc:68374] |
| Ensembl ID | ENSRNOG00000017817 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 4i1 |
| Synonyms | CcO IVi1, COX, COX4, COX4-1, COX4A, COX4I, COXIV, COX IV-1, cytochrome c oxidase subunit 4I1, IV-1, MC4DN16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cox4i1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_IV
- signal peptide
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cox4i1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- Leigh syndrome
- insulin resistance
- leprosy
- nuclear type 16 mitochondrial complex IV deficiency
- ductal breast carcinoma
- ductal breast cancer
- nuclear type 1 mitochondrial complex iv deficiency
role in cell
- expression in
- production in
- induction in
- growth
- osteoclastogenesis
- senescence
- phagocytosis by
- glycolysis in
- glycolytic flux in
- permeability transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- cytosol
- Golgi membrane
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
- nucleoplasm
- mitoplasts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cox4i1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- membrane
- mitochondrion
- cytosol
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity