Oasl Gene Summary [Rat]
Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; interleukin-27-mediated signaling pathway; and positive regulation of RIG-I signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oasl |
| Official Name | 2'-5'-oligoadenylate synthetase-like [Source:RGD Symbol;Acc:1308586] |
| Ensembl ID | ENSRNOG00000001187 |
| Bio databases IDs | |
| Aliases | 2'-5'-oligoadenylate synthetase-like |
| Synonyms | 2'-5'-oligoadenylate synthetase-like, OASL1, OASLd, p59-OASL, TRIP-14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oasl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Ubl1_cv_Nsp3_N-like
- double-stranded RNA binding
- Ubiquitin homologues
- enzyme
- protein binding
- ubiquitin-like domain
- thyroid hormone receptor binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- skin cancer
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- lung cancer
- polyglandular autoimmune syndrome type 1
- systemic sclerosis
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- signaling in
- production in
- replication in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oasl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- defense response to virus
- positive regulation of RIG-I signaling pathway
- response to virus
- negative regulation of viral genome replication
- interleukin-27-mediated signaling pathway
- regulation of ribonuclease activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 2'-5'-oligoadenylate synthetase activity
- DNA binding
- protein binding
- RNA binding
- double-stranded RNA binding
- thyroid hormone receptor binding