OASL Gene Summary [Human]
Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | OASL |
| Official Name | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] |
| Ensembl ID | ENSG00000135114 |
| Bio databases IDs | |
| Aliases | 2'-5'-oligoadenylate synthetase like |
| Synonyms | 2'-5'-oligoadenylate synthetase-like, OASL1, OASLd, p59-OASL, TRIP-14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OASL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Ubl1_cv_Nsp3_N-like
- double-stranded RNA binding
- Ubiquitin homologues
- enzyme
- protein binding
- ubiquitin-like domain
- thyroid hormone receptor binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- skin cancer
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- lung cancer
- polyglandular autoimmune syndrome type 1
- systemic sclerosis
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- signaling in
- production in
- replication in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OASL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- defense response to virus
- positive regulation of RIG-I signaling pathway
- response to virus
- negative regulation of viral genome replication
- interleukin-27-mediated signaling pathway
- regulation of ribonuclease activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 2'-5'-oligoadenylate synthetase activity
- DNA binding
- protein binding
- RNA binding
- double-stranded RNA binding
- thyroid hormone receptor binding