Hvcn1 Gene Summary [Rat]
Predicted to enable protein homodimerization activity and voltage-gated proton channel activity. Involved in positive regulation of superoxide anion generation and regulation of intracellular pH. Located in apical plasma membrane. Used to study middle cerebral artery infarction. Orthologous to human HVCN1 (hydrogen voltage gated channel 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hvcn1 |
| Official Name | hydrogen voltage-gated channel 1 [Source:RGD Symbol;Acc:1310788] |
| Ensembl ID | ENSRNOG00000001270 |
| Bio databases IDs | |
| Aliases | hydrogen voltage-gated channel 1 |
| Synonyms | 0610039P13Rik, BTS, HV1, hydrogen voltage-gated channel 1, mVSOP, RGD1310788, VSOP, Vsop. |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hvcn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal membrane-localization domain of ion-channel, VCN1
- voltage-gated proton channel
- protein homodimerization
- protein binding
- identical protein binding
- voltage-gated ion channel
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperglycemia
- chronic lymphocytic leukemia
- septic shock
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- decreased insulin secretion
- impaired glucose tolerance
- streptozotocin-induced diabetes
phenotypes
- decreased mean systemic arterial blood pressure
- decreased systemic arterial blood pressure
- Brain Edema
- Brain Infarction
- middle cerebral artery infarction
- transient cerebral ischemia
- cerebral edema
role in cell
- proliferation
- activation
- phosphorylation in
- expression in
- migration
- growth
- quantity
- number
- size
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- granules
- specific granule membrane
- apical membrane
- sperm tail
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hvcn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of acrosome reaction
- regulation of intracellular pH
- response to zinc ion
- cellular response to zinc ion
- innate immune response
- cell redox homeostasis
- response to pH
- cellular response to pH
- single fertilization
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- membrane
- phagocytic vesicle membrane
- sperm flagellum
- ion channel complex
- apical plasma membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- voltage-gated proton channel activity
- voltage-gated cation channel activity