Mx1 Gene Summary [Rat]
Predicted to enable GTPase activity; identical protein binding activity; and microtubule binding activity. Involved in response to virus. Located in nucleus. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mx1 |
| Official Name | myxovirus (influenza virus) resistance 1 [Source:RGD Symbol;Acc:3127] |
| Ensembl ID | ENSRNOG00000001959 |
| Bio databases IDs | |
| Aliases | myxovirus (influenza virus) resistance 1 |
| Synonyms | IFI78, Mx1, MXB, MX dynamin like GTPase 1, MX dynamin-like GTPase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynamin GTPase effector domain
- GTP binding
- Dynamin central region
- GTPase
- central domain
- enzyme
- assembly domain
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Dynamin family
Pathways
Biological processes and signaling networks where the Mx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nuclear pores
- nuclear envelope