Hectd4 Gene Summary [Rat]
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in glucose homeostasis and glucose metabolic process. Orthologous to human HECTD4 (HECT domain E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hectd4 |
| Official Name | HECT domain E3 ubiquitin protein ligase 4 [Source:RGD Symbol;Acc:1309762] |
| Ensembl ID | ENSRNOG00000001352 |
| Bio databases IDs | |
| Aliases | HECT domain E3 ubiquitin protein ligase 4 |
| Synonyms | A130010L24, AF-1 specific protein phosphatase, BC019639, C12ord51, C12orf51, EG545802, FLJ30092, Gm15800, HECT domain E3 ubiquitin protein ligase 4, HEEL, LOC100287871, mKIAA0614, NEDSSCC, POTAGE, RGD1309762 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hectd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- SPRY domain
- Domain Homologous to E6-AP Carboxyl Terminus with
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- pervasive developmental disorder
- coronary artery disease
- neurodevelopmental disorder with seizures, spasticity, and complete or partial agenesis of the corpus callosum
- neurodevelopmental disorder with seizures, spasticity, and complete agenesis of the corpus callosum
- myocardial infarction
- esophageal carcinoma
regulated by
regulates
- D-glucose
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hectd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucose homeostasis
- glucose metabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding