Ache Gene Summary [Rat]
Enables acetylcholine binding activity and acetylcholinesterase activity. Involved in several processes, including acetylcholine catabolic process; nervous system development; and positive regulation of neurogenesis. Located in several cellular components, including endoplasmic reticulum lumen; membrane raft; and synaptic membrane. Is active in neuromuscular junction and synaptic cleft. Biomarker of acute stress disorder and leptospirosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; drug dependence (multiple); epilepsy; myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ache |
| Official Name | acetylcholinesterase [Source:RGD Symbol;Acc:69313] |
| Ensembl ID | ENSRNOG00000050841 |
| Bio databases IDs | |
| Aliases | acetylcholinesterase |
| Synonyms | Acchoease, ACEE, Acetylcholine esterase, acetylcholinesterase, acetylcholinesterase (Yt blood group), ACHEst, ARACHE, Cholinesterase, HACHE, YT |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ache often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carboxylesterase family
- alpha/beta hydrolases
- enzyme
- Acetylcholinesterase tetramerization domain
- protein binding
- beta-amyloid binding
- identical protein binding
- cholinesterase
- alpha/beta hydrolase fold
- acetylcholinesterase homology domain
- binding protein
- acetylcholinesterase
- laminin binding
- collagen binding
- serine hydrolase
- protein homodimerization
- hydrolase
- acetylcholine binding
Pathways
Biological processes and signaling networks where the Ache gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fatigue
- osteoarthritis
- sepsis
- vomiting
- nausea
- Huntington disease
- chronic obstructive pulmonary disease
- dementia
- neurological disorder
- Alzheimer disease
role in cell
- phosphorylation in
- expression in
- activation
- quantity
- apoptosis
- proliferation
- cell death
- activation in
- degradation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- reticular perinuclear compartment
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- outer nuclear membrane
- nuclear envelope
- sperm head
- neuromuscular junctions
- axonal membrane
- nerve ending
- synapse
- rough endoplasmatic reticulum
- basal lamina
- membrane rafts
- motor endplates
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- exosomes
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ache gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetylcholine catabolic process
- retina development in camera-type eye
- nervous system development
- cell adhesion
- osteoblast development
- amyloid precursor protein metabolic process
- synapse assembly
- negative regulation of synaptic transmission, cholinergic
- acetylcholine catabolic process in synaptic cleft
- positive regulation of protein secretion
- receptor internalization
- regulation of receptor recycling
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- synapse
- extracellular region
- plasma membrane
- cell surface
- nucleus
- basement membrane
- extracellular space
- perinuclear region of cytoplasm
- synaptic cleft
- membrane
- neuromuscular junction
Molecular Function
What the gene product does at the molecular level
- serine hydrolase activity
- protein binding
- protein homodimerization activity
- collagen binding
- acetylcholine binding
- acetylcholinesterase activity
- laminin binding
- beta-amyloid binding
- cholinesterase activity
- hydrolase activity