Lrch4 Gene Summary [Rat]
Predicted to be involved in membrane raft assembly and positive regulation of toll-like receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in PML body. Orthologous to human LRCH4 (leucine rich repeats and calponin homology domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrch4 |
| Official Name | leucine rich repeats and calponin homology domain containing 4 [Source:RGD Symbol;Acc:1306145] |
| Ensembl ID | ENSRNOG00000001402 |
| Bio databases IDs | |
| Aliases | leucine rich repeats and calponin homology domain containing 4 |
| Synonyms | 2810008P14Rik, 2900069C24Rik, leucine-rich repeats and calponin homology (CH) domain containing 4, leucine rich repeats and calponin homology domain containing 4, LRN, LRRN1, LRRN4, PP14183, SAP25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrch4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- transcription regulator
- LXXLL motif
- Calponin homology domain
- Leucine rich repeat
- calponin homology (CH) domain superfamily
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrch4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane raft assembly
- positive regulation of toll-like receptor signaling pathway
- nervous system development
Cellular Component
Where in the cell the gene product is active
- PML body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding