Kdm5b Gene Summary [Rat]
Predicted to enable several functions, including histone H3K4me/H3K4me2/H3K4me3 demethylase activity; transcription corepressor activity; and zinc ion binding activity. Involved in cellular response to fibroblast growth factor stimulus; lens fiber cell differentiation; and response to fungicide. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 65; breast cancer; and high grade glioma. Orthologous to human KDM5B (lysine demethylase 5B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm5b |
| Official Name | lysine demethylase 5B [Source:RGD Symbol;Acc:1565602] |
| Ensembl ID | ENSRNOG00000060544 |
| Bio databases IDs | |
| Aliases | lysine demethylase 5B |
| Synonyms | 2010009J12Rik, 2210016I17Rik, CT31, D1Ertd202e, JARID1B, lysine demethylase 5B, mKIAA4034, MRT65, PLU-1, PPP1R98, PUT1, Rb-Bp2, RBBP2H1A, RBP2-H1, RGD1565602 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kdm5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- jmjN domain
- nucleic acid binding
- PLU-1-like protein
- 2-oxoglutarate:oxygen oxidoreductase
- transcription co-repressor
- enzyme
- protein binding
- sequence-specific DNA binding
- ARID/BRIGHT DNA binding domain
- RmlC-like cupin superfamily
- DNA binding
- C5HC2 zinc finger
- zinc ion binding
- double-stranded DNA binding
- PHD finger superfamily
- histone demethylase activity
- ARID/BRIGHT DNA binding domain family
Pathways
Biological processes and signaling networks where the Kdm5b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- pervasive developmental disorder
- autosomal recessive mental retardation type 65
- hereditary disorder
- acute myeloid leukemia
- neurodevelopmental disorder
- papillary thyroid carcinoma
- papillary thyroid cancer
- mental retardation
role in cell
- proliferation
- expression in
- binding in
- growth
- mitosis
- colony formation by
- number
- accumulation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kdm5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to fungicide
- post-embryonic development
- cellular response to fibroblast growth factor stimulus
- regulation of transcription, DNA-dependent
- branching involved in mammary gland duct morphogenesis
- mammary duct terminal end bud growth
- uterus morphogenesis
- single fertilization
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- rhythmic process
- positive regulation of gene expression
- regulation of estradiol secretion
- lens fiber cell differentiation
- positive regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- DNA binding
- zinc ion binding
- protein binding
- transcription corepressor activity
- histone binding
- histone demethylase activity
- histone demethylase activity (H3-K4 specific)
- histone demethylase activity (H3-trimethyl-K4 specific)