Acap2 Gene Summary [Rat]
Predicted to enable GTPase activator activity; phosphatidylinositol-3,5-bisphosphate binding activity; and small GTPase binding activity. Involved in cellular response to nerve growth factor stimulus and endocytic recycling. Located in endosome membrane. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acap2 |
| Official Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [Source:RGD Symbol;Acc:1562939] |
| Ensembl ID | ENSRNOG00000001730 |
| Bio databases IDs | |
| Aliases | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
| Synonyms | 4832442G16, 9530039J15Rik, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2, CENTB2, CNT-B2, LOC360727, mKIAA0041 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Bin/Amphiphysin/Rvs domain
- phosphatidylinositol binding
- Ankyrin repeat
- BAR domain of APPL family
- binding protein
- Putative GTP-ase activating proteins for the small GTPase, ARF
- PH domain
- BAR domain
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- prostate cancer
- severe acute respiratory syndrome
- fracture of bone
- kidney disease
- glomerulonephritis
regulated by
- mir-193 (includes others)
role in cell
- exocytosis
- exocytosis by
- cell viability
- expression in
- outgrowth
- formation
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ruffle
- Plasma Membrane
- cytosol
- plasma membrane projections
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament-based process
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- membrane
- ruffle
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity