Mapt Gene Summary [Rat]
Enables several functions, including Hsp90 protein binding activity; enzyme binding activity; and protein-folding chaperone binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; mRNA transport; and positive regulation of long-term synaptic depression. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and neuronal cell body. Used to study brain disease (multiple); cognitive disorder (multiple); obesity; and tauopathy (multiple). Biomarker of middle cerebral artery infarction and traumatic brain injury. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapt |
| Official Name | microtubule-associated protein tau [Source:RGD Symbol;Acc:69329] |
| Ensembl ID | ENSRNOG00000005133 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein tau |
| Synonyms | ALZ50, AW045860, DDPAC, FTD1, FTDP-17, MAPT 0N4R, MAPT 1N4R, MAPT 2N4R, MAPTL, microtubule-associated protein tau, MSTD, Mtapt, MTBT1, MTBT2, PHF-tau, PPND, PPP1R103, pTau, RNPTAU, TAU, Tau-1, Tau 3r, TAU4R, TAU-FACTOR, Tau-PHF6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mapt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein repeat
- Tau and MAP protein, tubulin-binding repeat
- inter-repeat domain
- heat shock protein binding
- protein binding activity, bridging
- identical protein binding
- proline rich domain
- K18 repeat domain
- tau repeat region
- AT DNA binding
- projection domain
- tubulin binding domain
- cytoskeletal protein binding
- actin binding
- serine phosphorylation site
- chaperone binding
- microtubule binding repeat
- microtubule binding domain
- PXXP Class I motif
- protein kinase binding
- KIGS motif
- protein phosphatase binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- phosphatidylinositol binding
- DNA binding
- SH3-domain binding
- RNA binding
- phosphorylation site
- microtubule binding
- binding protein
- Ser/Thr-Pro site
- single-stranded DNA binding
- double-stranded DNA binding
- C-terminal assembly domain
- PXXP motif
- KCGS motif
Pathways
Biological processes and signaling networks where the Mapt gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- demyelination
- cognitive impairment
- COVID-19
- Alzheimer disease
- tauopathy
- Parkinson disease
- behavioral deficit
- weight loss
- destabilization of medial meniscus-induced osteoarthritis
role in cell
- phosphorylation in
- expression in
- cell death
- production in
- migration
- loss
- loss in
- activation in
- organization
- organization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- microtubule fractions
- nuclear fraction
- soluble fraction
- detergent-insoluble fractions
- microtubule cytoskeleton
- microtentacles
- axon component
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- somatodendritic region
- perinuclear region
- cellular membrane
- filamentous network
- cell cortex
- Nucleus
- vacuole
- endosomes
- centrosome
- centriole
- Mitochondria
- membrane compartment
- microtubules
- axonemes
- actin filaments
- microtubule bundles
- granules
- cytosol
- cytoplasmic face of plasma membrane
- nucleoli
- nuclear speckles
- coiled body
- dendritic spines
- axonal membrane
- growth cone
- neurites
- dendrite initial segments
- glial cell projections
- extracellular matrix
- membrane rafts
- cellular protrusions
- membrane processes
- filopodia
- mitotic spindle
- chromosomal arms
- perikaryon
- axons
- dendrites
- postsynaptic density
- plasma
- lamellipodia
- mossy fibers
- detergent-soluble fraction
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mapt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitochondrial fission
- regulation of microtubule cytoskeleton organization
- regulation of chromosome organization
- regulation of cellular response to heat
- regulation of long term synaptic depression
- central nervous system neuron development
- generation of neurons
- memory
- astrocyte activation
- cellular response to heat
- negative regulation of mitochondrial membrane potential
- rRNA metabolic process
- regulation of synaptic plasticity
- plus-end-directed organelle transport along microtubule
- regulation of microtubule polymerization
- regulation of microtubule polymerization or depolymerization
- negative regulation of kinase activity
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of microtubule polymerization
- stress granule assembly
- synapse organization
- neuron projection development
- cell-cell signaling
- internal protein amino acid acetylation
- microtubule polymerization
- positive regulation of axon extension
- regulation of mitochondrial fission
- microtubule cytoskeleton organization
- response to DNA damage stimulus
- negative regulation of gene expression
- microglial cell activation
- protein polymerization
- intracellular distribution of mitochondria
- regulation of autophagy
- regulation of calcium-mediated signaling
- axon transport of mitochondrion
- cytoplasmic microtubule organization
- response to lead ion
- cellular response to reactive oxygen species
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- nuclear speck
- neuronal cell body
- extracellular region
- main axon
- neuron projection
- plasma membrane
- microtubule
- growth cone
- dendrite
- nucleus
- tubulin complex
- cytoplasm
- cell body
- dendritic spine
- mitochondrion
- membrane raft
- membrane
- cytosol
- axolemma
- nuclear periphery
- axon
Molecular Function
What the gene product does at the molecular level
- apolipoprotein binding
- protein kinase binding
- identical protein binding
- dynactin binding
- phosphatidylinositol binding
- double-stranded DNA binding
- AT DNA binding
- sequence-specific DNA binding
- microtubule binding
- single-stranded DNA binding
- DNA binding
- protein binding
- RNA binding
- actin binding
- chaperone binding
- Hsp90 protein binding
- SH3 domain binding
- lipoprotein particle binding
- protein binding, bridging
- protein phosphatase 2A binding
- enzyme binding