Dspp Gene Summary [Rat]
Enables collagen binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; mandibular condyle articular cartilage development; and odontoblast differentiation. Acts upstream of or within positive regulation of calcium ion import. Located in collagen-containing extracellular matrix; nucleus; and plasma membrane. Biomarker of osteoporosis. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dspp |
| Official Name | dentin sialophosphoprotein [Source:RGD Symbol;Acc:2525] |
| Ensembl ID | ENSRNOG00000002168 |
| Bio databases IDs | |
| Aliases | dentin sialophosphoprotein |
| Synonyms | Dentin phosphophoryn, dentin sialophosphoprotein, DFNA39, DGI1, Dmp2, DMP3, DPP, DSP, Phosphophorin, Pp, RDSP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dspp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium ion binding
- extracellular matrix structural constituent
- collagen binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dentinogenesis imperfecta Shields type II
- deafness, autosomal dominant 39 with dentinogenesis imperfecta 1
- dentinogenesis imperfecta - Shields type III
- dentin dysplasia, type II
- sporadic age-related sensorineural hearing loss
- dentinogenesis imperfecta
- hereditary disorder
- early-onset high myopia
role in cell
- expression in
- proliferation
- differentiation
- formation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dspp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dentinogenesis
- odontoblast differentiation
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- collagen binding
- calcium ion binding
- extracellular matrix structural constituent