Chic2 Gene Summary [Rat]
Predicted to be located in Golgi apparatus. Predicted to be active in Golgi-associated vesicle and plasma membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CHIC2 (cysteine rich hydrophobic domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chic2 |
| Official Name | cysteine-rich hydrophobic domain 2 [Source:RGD Symbol;Acc:1309278] |
| Ensembl ID | ENSRNOG00000002267 |
| Bio databases IDs | |
| Aliases | cysteine-rich hydrophobic domain 2 |
| Synonyms | 1700081B18Rik, 4930502K01Rik, BTL, cysteine-rich hydrophobic domain 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chic2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Golgin subfamily A member 7/ERF4 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hematological neoplasia
- migraines
- acute myeloid leukemia
- myeloid/lymphoid neoplasm with eosinophilia
regulated by
- nitric oxide
- NR3C1
- E. coli B4 lipopolysaccharide
regulates
role in cell
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chic2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- Golgi apparatus
- Golgi-associated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding