Csf2rb Gene Summary [Rat]
Predicted to enable coreceptor activity and cytokine receptor activity. Involved in response to lipopolysaccharide. Predicted to be part of granulocyte macrophage colony-stimulating factor receptor complex. Predicted to be active in external side of plasma membrane. Used to study asthma. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csf2rb |
| Official Name | colony stimulating factor 2 receptor beta common subunit [Source:RGD Symbol;Acc:620189] |
| Ensembl ID | ENSRNOG00000000187 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 2 receptor beta common subunit |
| Synonyms | AI848964, AIC2B, Bc, Beta C, betaGMR, beta IL-3, CD131, CDw131, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), colony stimulating factor 2 receptor subunit beta, colony stimulating factor 2 receptor subunit β, colony stimulating factor 2 receptor, β, low-affinity (granulocyte-macrophage), Csf2r, Csf2rb1, Csfgmrb, Gm-csfr beta IT, Gm csf receptor β, Gmcsf receptor β c, GM-CSFR β, Gm-csfr β IT, Gmr β c, Granulocyte-macrophage colony stimulating factor 2 receptor, beta 1, Granulocyte-macrophage colony stimulating factor 2 receptor, β 1, Il3r, IL3RB, Il3rb1, IL3R beta 1, IL3R β 1, IL5RB, Il-5Rbetac, Il-5 receptor β chain, Il-5Rβc, SMDP5, β C, β chain of il 3 receptor, β IL-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Csf2rb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endodomain
- extracellular domain
- interleukin-5 receptor
- Box motif
- signaling receptor activity
- Purple acid Phosphatase, N-terminal domain
- Fibronectin type 3 domain
- Interferon-alpha/beta receptor, fibronectin type III
- interleukin-3 receptor
- protein binding
- Hemopoietin domain
- TRAF6 binding domain
- Box I domain
- Box II domain
- N-linked glycosylation site
- cytoplasmic domain
- FN3
- extracellular ligand binding domain
- transmembrane domain
- intracellular domain
- membrane-proximal domain
- transmembrane receptor
- tyrosine phosphorylation site
- coreceptor
Pathways
Biological processes and signaling networks where the Csf2rb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic myeloid leukemia
- atopic dermatitis
- HIV infection
- cytomegalovirus retinitis
- sarcoma
- rheumatoid arthritis
- infection
- ankylosing spondylitis
- lymphoma
- graft-vs-host disease
role in cell
- proliferation
- cell viability
- phosphorylation in
- survival
- apoptosis
- activation in
- growth
- migration
- expression in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- vesicles
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Csf2rb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- granulocyte-macrophage colony-stimulating factor signaling pathway
- signal transduction
- interleukin-5-mediated signaling pathway
- interleukin-3-mediated signaling pathway
- cytokine-mediated signaling pathway
- immunoglobulin mediated immune response
- positive regulation of leukocyte proliferation
- response to lipopolysaccharide
- respiratory gaseous exchange
- cellular response to interleukin-3
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- granulocyte macrophage colony-stimulating factor receptor complex
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- interleukin-3 receptor activity
- signaling receptor activity
- interleukin-5 receptor activity
- cytokine receptor activity