Brwd3 Gene Summary [Rat]
Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 93. Orthologous to human BRWD3 (bromodomain and WD repeat domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brwd3 |
| Official Name | bromodomain and WD repeat domain containing 3 [Source:RGD Symbol;Acc:1559445] |
| Ensembl ID | ENSRNOG00000002291 |
| Bio databases IDs | |
| Aliases | bromodomain and WD repeat domain containing 3 |
| Synonyms | BRODL, bromodomain and WD repeat domain containing 3, D030064D06Rik, DCAF20, Gm10452, Gm596, MRX93, RGD1559445, XLID93 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brwd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- Bromodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- mental retardation
- hereditary disorder
- X linked mental retardation with microcephaly
- pervasive developmental disorder
- neurodevelopmental disorder
- angina pectoris
- syndromic X-linked mental retardation
regulated by
- EGLN
- dimethyl n-oxalyl-glycine
role in cell
- organization
- binding in
- homologous recombination repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brwd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus