Ddb1 Gene Summary [Rat]
Enables damaged DNA binding activity. Predicted to be involved in several processes, including UV-damage excision repair; positive regulation by virus of viral protein levels in host cell; and positive regulation of metabolic process. Predicted to act upstream of or within several processes, including Wnt signaling pathway; negative regulation of apoptotic process; and proteasomal protein catabolic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleolus and site of double-strand break. Human ortholog(s) of this gene implicated in communication disorder. Orthologous to human DDB1 (damage specific DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddb1 |
| Official Name | damage-specific DNA binding protein 1 [Source:RGD Symbol;Acc:621889] |
| Ensembl ID | ENSRNOG00000020715 |
| Bio databases IDs | |
| Aliases | damage-specific DNA binding protein 1 |
| Synonyms | damage-specific DNA binding protein 1, DDBA, DNA-damage-binding protein 1, p127-Ddb1, UV-DDB1, WHIKERS, Xap1, XPCE, XPE, XPE-BF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- damaged DNA binding
- protein binding activity, bridging
- Mono-functional DNA-alkylating methyl methanesulfonate N-term
- protein domain specific binding
- protein binding
- DNA binding
- CPSF A subunit region
Pathways
Biological processes and signaling networks where the Ddb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- actinic keratosis
- epithelial cancer
- White-Kernohan syndrome
- lichen planus
- sarcomatoid nasopharyngeal carcinoma
- sarcomatoid cancer
- nasopharyngeal cancer
- complete testicular feminization syndrome
- high-fat diet-induced obesity
- nasopharyngeal carcinoma
role in cell
- expression in
- number
- proliferation
- apoptosis
- phosphorylation in
- G2/M phase
- binding in
- growth
- binding
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- nucleotide-excision repair
- spindle assembly involved in female meiosis
- negative regulation of developmental process
- regulation of circadian rhythm
- positive regulation of gluconeogenesis
- apoptotic process
- cellular response to UV
- Wnt receptor signaling pathway
- positive regulation of viral genome replication
- interaction with symbiont
- proteasomal protein catabolic process
- UV-damage excision repair
- germ cell programmed cell death
- positive regulation of protein catabolic process
- response to DNA damage stimulus
- positive regulation of viral protein levels in host cell
- ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- rhythmic process
- release of virus from host
- negative regulation of apoptotic process
- negative regulation of reproductive process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- nucleolus
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
- nucleus
- chromosome, telomeric region
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- Cul4A-RING ubiquitin ligase complex
- Cul4B-RING ubiquitin ligase complex
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- damaged DNA binding
- protein binding, bridging
- WD40-repeat domain binding