Brwd1 Gene Summary [Rat]
Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including axoneme; motile cilium; and nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human BRWD1 (bromodomain and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brwd1 |
| Official Name | bromodomain and WD repeat domain containing 1 [Source:RGD Symbol;Acc:1309030] |
| Ensembl ID | ENSRNOG00000001632 |
| Bio databases IDs | |
| Aliases | bromodomain and WD repeat domain containing 1 |
| Synonyms | 5330419I02Rik, bromodomain and WD repeat domain containing 1, C21orf107, CILD51, D530019K20RIK, DCAF19, G1-403-16, LOC100911399, N143, repro5, WDR9, WRD9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brwd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Bromodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary myelofibrosis
- Hutchinson-Gilford progeria syndrome
- primary ciliary dyskinesia type 51
- primary ciliary dyskinesia
- atrial fibrillation
- premature ovarian failure
- Down syndrome
- metabolic syndrome X
- osteoarthritis
- pervasive developmental disorder
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- BRWD1
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- axonemes
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brwd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- motile cilium
- cytosol
- cilium membrane
- nucleolus
- axoneme
- nucleoplasm