Ptpn4 Gene Summary [Rat]
Predicted to enable glutamate receptor binding activity and non-membrane spanning protein tyrosine phosphatase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn4 |
| Official Name | protein tyrosine phosphatase, non-receptor type 4 [Source:RGD Symbol;Acc:620712] |
| Ensembl ID | ENSRNOG00000002625 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 4 |
| Synonyms | hPTP-MEG, MEG, protein tyrosine phosphatase non-receptor type 4, protein tyrosine phosphatase, non-receptor type 4, Ptn4, PTPMEG, PTPMEG1, TEP, TEP/mPTPMEG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptpn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- FERM central domain
- Band 4.1 homologues
- non-membrane spanning protein tyrosine phosphatase
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- canonical PDZ domain
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- PTP_DSP_cys
- PDZ domain
- Protein tyrosine phosphatase, catalytic domain motif
- FERM N-terminal domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- FERM adjacent (FA)
- Protein-tyrosine phosphatase
- Ubl1_cv_Nsp3_N-like
- phosphatase
- FERM domain B-lobe
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the Ptpn4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- neurodevelopmental disorder
- pancreatic epithelial cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- pancreatic adenocarcinoma
- mental retardation
role in cell
- long term synaptic depression
- degranulation
- healing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- cellular membrane
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptpn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cytosol
- nucleoplasm
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- cytoskeletal protein binding